Product ID:4456 ULTANE SEVOFLURANE
MSDS Date:12/23/1998
FSC:NIIN:Submitter:F BT
Status Code:A
MSDS Number: CLCDK

Emergency Phone: 1-847-937-7970

Info Phone: 847-937-3386

Preparer: DLF

Cage: 33110

Telephone: 847-935-7177

Cage: 33110

SEVOFLURANE

CAS: 28523-86-6

RTECS: KO0737000

Routes of Entry: Inhalation:YES Skin:UNKNOWN Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:THIS MATERIAL IS USED TO PRODUCE
ANESTHESIA (SLEEP). TARGET ORGANS INCLUDE THE CENTRAL NERVOUS
SYSTEM, RESPIRATORY SYSTEM, CARDIOVASCULAR SYSTEM & POSSIBLY THE
FETUS.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:SEVOFLURANE PRODUCES ANESTHESIA W/SYMPTOMS OF:
RESPIRATORY DEPRESSION, HYPOTENSION, BRADYCARDIA, SHIVERING,
NAUSEA, HEADACHE. LARGE CONCENTRATIONS OF SEVOFLURANE HAVE
PRODUCED SLIGHT ELEVATIONS IN SE RUM ENZYMES & PRODUCED MATERNAL
EFFECTS, FETAL EFFECTS (DECREASED WEIGHT GAINS), CLEFT PALATE &
DECREASED REPRODUCTIVE PERFORMANCE IN ANIMAL STUDIES.
Medical Cond Aggravated by Exposure:PATIENTS SENSITIVE TO HALOGENATED
ANESTHETICS; CARDIOVASCULAR/RESPIRATORY DISEASES.

First Aid:EYES/SKIN/INGESTION/INHALATION: REMOVE FROM SOURCE OF
EXPOSURE. FLUSH SKIN & EYES W/COPIOUS AMOUNTS OF WATER. PROVIDE
SYMPTOMATIC/SUPPORTIVE CARE, MAINTAINING VENTILATION W/PURE OXYGEN
AS NECESSARY.

Flash Point:NON-FLAMMABLE
Autoignition Temp:Autoignition Temp Text:N/D
Lower Limits:N/D
Upper Limits:N/D
Extinguishing Media:WATER SPRAY, CO2/DRY CHEMICAL POWDER
Fire Fighting Procedures:WEAR SELF CONTAINED BREATHING APPARATUS.
Unusual Fire/Explosion Hazard:AVOID INHALATION OF COMBUSTION PRODUCTS.

Spill Release Procedures:VENTILATE AREA & WASH SITE AFTER MATERIAL WIPE
UP IS COMPLETE. COLLECT AS POISONOUS ORGANIC CHEMICAL, PLACE IN
CONTAINER & HOLD FOR WASTE DISPOSAL.

Handling and Storage Precautions:STORE AT CONTROLLED ROOM TEMPERATURE
OF 59-86F. KEEP CONTAINERS CLOSED & AWAY FROM LIGHT.

Respiratory Protection:IF ENGINEERING CONTROLS ARE IN PLACE,
RESPIRATORS ARE GENERALLY NOT REQUIRED. ENTRY INTO AREAS OF UNKNOWN
AIRBORNE CONCENTRATION OF THIS PRODUCT SHOULD ONLY BE MADE W/A SELF
CONTAINED BREATHING APPARA TUS.
Ventilation:IN THE LABORATORY ENVIRONMENT, THIS PRODUCT SHOULD BE
HANDLED IN A HOOD.
Protective Gloves:IMPERVIOUS
Eye Protection:UNDER NORMAL USE CONDITIONS, NO PROTECTION IS
ANTICIPATED.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

Boiling Pt:=58.6C, 137.5F
Vapor Pres:245.5
Vapor Density:6.94
Spec Gravity:1.525
pH:7-7.5
Evaporation Rate & Reference:HIGHLY VOLATILE
Solubility in Water:0.01
Appearance and Odor:CLEAR, COLORLESS LIQUID

Stability Indicator/Materials to Avoid:YES
ALKALINE EARTH METALS, STRONG BASES
Hazardous Decomposition Products:CO, CO2, HYDROGEN FLUORIDE

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
FEDERAL REGULATIONS.

Toxicological Information:ORAL: LD50=10,800-37,200 MG/KG IN MICE AND
RATS. INHALATION: LC50=58,000-83,000 PPM/1H IN RATS AND MICE,
28,300-29,000 PPM/3 H IN RATS AND MICE, 33,000-45,000 PPM/3H IN
7-14 DAY OLD NEONATAL RATS AND MICE, 73,000-106,000 PPM/1H IN DOGS
AND RABBITS AND 68,000 PPM/3H IN MONKEYS. OCULAR IRRITATION:
SEVOFLURANE WAS SLIGHTLY IRRITATING IN AN EYE IRRITATION TEST IN
RABBITS. SPECIAL TARGET ORGAN EFFECTS: CLINICALLY, SEVOFLURANE
PRODUCES ANESTHESIA WITH A MINIMUM ALVEOLAR CONCENTRATION OF 20,000
PPM. A SMALL AMOUNT OF AN INSPIRED DOSE IS METABOLIZED TO FLUORIDE
AND A FLUORIDE CONTAINING METABOLITE.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Transport Information:IATA/ICA0 STATUS: REGULATED; PROPER SHIPPING
NAME: AVIATION REGULATED LIQUID, N.O.S. (SEVOFLURANE).; HAZARD
CLASS: 9; UN NUMBER: UN3334